Ma lalo o nā kūlana physiological, ʻo ke kuleana o ka thrombosis ke hoʻōki i ke koko.ʻO ka hoʻoponopono ʻana i nā ʻiʻo a me nā ʻōpū e hoʻopau mua i ke koko.He coagulopathy ka hemophilia ma muli o ka nele o nā mea coagulation.He mea paʻakikī ke hana ʻana i ka thrombus ma ka ʻāpana ʻeha a ʻaʻole hiki ke hoʻōki pono i ke koko a hoʻoulu i ke koko.Loaʻa ka hapa nui o ka hemostatic thrombosis a aia ma waho o ke kīʻaha koko a i ʻole kahi i haki ai ke kīʻaha koko.

Inā hoʻokumu ʻia ke koko i loko o kahi kīʻaha koko, paʻa ke kahe o ke koko, hoʻemi ʻia ke kahe koko, a i ʻole ke kahe ʻana o ke koko.Inā loaʻa ka thrombosis i loko o ke aʻa, e hoʻoulu ʻia ka ischemia o ke kino/tissue a me ka necrosis, e like me ka myocardial infarction, cerebral infarction, a me ka necrosis/amputation o lalo.ʻO ka thrombus i hana ʻia i loko o nā aʻa hohonu o nā ʻaoʻao haʻahaʻa ʻaʻole e pili wale i ke kahe ʻana o ke koko venous i loko o ka puʻuwai a hoʻoulu i ka pehu o nā ʻaoʻao haʻahaʻa, akā hāʻule pū nō hoʻi ma o ka vena cava inferior, atrium ʻākau a me ka ventricle ʻākau e komo a hoʻopaʻa ʻia i loko. ʻo ke aʻaʻa pulmonary, ka hopena i ka pulmonary embolism.Nā maʻi me ka nui o ka make.

Hoʻomaka ka thrombosis

I ka hapanui o nā hihia, ʻo ka loulou mua o ka thrombosis ka hōʻeha, hiki ke hōʻeha, ka ʻokiʻoki, ka haki ʻana o ka plaque i loko o nā aʻa, a i ʻole ka pōʻino endothelial i hoʻokumu ʻia e ka maʻi, ka palekana a me nā mea ʻē aʻe.ʻO kēia kaʻina hana o ka thrombus i hoʻomaka ʻia e ka ʻeha i kapa ʻia ʻo ka exogenous coagulation system.I kekahi mau hihia, hiki i ka stasis koko a i ʻole ka lohi o ke kahe ʻana o ke koko ke hoʻomaka i ke kaʻina o ka thrombosis, ʻo ia ke ala o ka hoʻāla ʻana, i kapa ʻia ʻo ka endogenous coagulation system.

ʻO ka hemostasis mua

Ke hoʻopilikia ka ʻeha i nā kīʻaha koko, pili mua nā platelets e hana i kahi papa hoʻokahi e uhi ai i ka ʻeha, a laila hoʻāla ʻia e hōʻuluʻulu e hana i nā clumps, ʻo ia ka platelet thrombi.Kapa ʻia ka hana holoʻokoʻa he hemostasis mua.

ʻO ka hemostasis lua

Hoʻokuʻu ka ʻeha i kahi mea coagulation i kapa ʻia ʻo tissue factor, kahi e hoʻomaka ai ka ʻōnaehana coagulation endogenous e hana i ka thrombin ma hope o ke komo ʻana i ke koko.ʻO ka Thrombin kahi mea hoʻoikaika e hoʻohuli i ka protein coagulation i loko o ke koko, ʻo ia hoʻi, fibrinogen i fibrin., Ua kapa 'ia ka hana holo'oko'a he hemostasis lua.

"Ka pilina maikaʻi loa"Thrombosis

I ke kaʻina hana o ka thrombosis, ʻo ka pae mua o ka hemostasis (platelet adhesion, activation and aggregation) a me ka lua o ka pae o ka hemostasis (thrombin production and fibrin formation) e hui pū kekahi me kekahi.Hiki ke hana maʻamau ʻia ka hemostasis lua ma ke alo o nā platelets, a ʻo ka thrombin i hana ʻia e hoʻāla hou i nā platelets.Hana pū nā mea ʻelua a hana pū e hoʻopau i ke kaʻina o ka thrombosis.