Aia nā ʻōnaehana coagulation a me anticoagulation i loko o ke koko kanaka.Ma lalo o nā kūlana maʻamau, mālama nā mea ʻelua i kahi kaulike ikaika e hōʻoia i ke kahe maʻamau o ke koko i loko o nā kīʻaha koko, a ʻaʻole e hana i ka thrombus.I ka hihia o ke koko haʻahaʻa, nele i ka wai inu, a me nā mea ʻē aʻe, e lohi ke kahe ʻana o ke koko, e hoʻopaʻa ʻia ke koko a viscous, e hyperactive ka hana coagulation a i ʻole e nāwaliwali ka hana anticoagulation, e uhaʻi i kēia kaulike. a hoʻolilo i nā kānaka i kahi "thrombotic state".Hiki ke loaʻa ka thrombosis ma nā wahi āpau o nā kīʻaha koko.Holo ka thrombus me ke koko i loko o nā kīʻaha koko.Inā noho ʻo ia i loko o ke aʻaʻa cerebral a poloka i ke kahe koko maʻamau o ke aʻaʻa cerebral, he thrombosis cerebral ia, kahi e hoʻoulu ai i ka maʻi ischemic.Hiki i nā kīʻaha coronary o ka puʻuwai ke hoʻoulu i ka myocardial infarction, ʻo ia hoʻi, ka thrombosis arterial haʻahaʻa, ka thrombosis hohonu hohonu, a me ka embolism pulmonary.

ʻO ka thrombosis, ʻo ka hapa nui o lākou e loaʻa nā hōʻailona koʻikoʻi i ka hoʻomaka mua ʻana, e like me ka hemiplegia a me ka aphasia ma muli o ka infarction cerebral;koʻikoʻi precordial colic i ka myocardial infarction;ʻeha nui o ka umauma, dyspnea, hemoptysis ma muli o ka pulmonary infarction;Hiki iā ia ke hōʻeha i nā wāwae, a i ʻole ke anuanu a me ka claudication intermittent.ʻO ka puʻuwai koʻikoʻi loa, ka maʻi cerebral infarction a me ka pulmonary infarction hiki ke make koke.Akā i kekahi manawa ʻaʻohe hōʻailona maopopo, e like me ka thrombosis hohonu hohonu o ka ʻaoʻao haʻahaʻa, ʻeha wale ka bipi a ʻoluʻolu ʻole.Manaʻo ka nui o nā poʻe maʻi ma muli o ka luhi a i ʻole ke anu, akā ʻaʻole lākou e noʻonoʻo nui, no laila ua maʻalahi ka nalo ʻana i ka manawa maikaʻi loa no ka mālama ʻana.He mea minamina loa no ka nui o nā kauka i maʻa hewa.Ke puka mai ka edema maʻamau o ka ʻaoʻao haʻahaʻa, ʻaʻole ia e lawe wale i nā pilikia i ka mālama ʻana, akā e waiho maʻalahi hoʻi i nā sequelae.