ʻO ke kaʻina hana thrombosis, me nā kaʻina 2:

1. Adhesion a aggregation o platelets i loko o ke koko

I ka wā mua o ka thrombosis, hoʻomau mau ʻia nā platelets mai ke kahe axial a pili i ka ʻili o nā ʻāpana collagen i hōʻike ʻia ma ka intima o nā kīʻaha koko i hōʻino ʻia.Hoʻohana ʻia nā platelets e ka collagen a hoʻokuʻu i nā mea e like me ADP, thromboxane A2, 5-AT a me platelet factor IV., He hopena koʻikoʻi kēia mau mea i ka hoʻopili ʻana i nā platelets, no laila e hoʻomau mau ʻia nā platelets i loko o ke kahe koko i ka ʻāina e hana i kahi puʻu platelet., ka hoomaka ana o ka venous thrombosis, ke poo o ka thrombus.

Hoʻopili nā platelets i ka ʻili o nā ʻāpana collagen i hōʻike ʻia ma ka intima o ke kīʻaha koko i hōʻino ʻia a hoʻāla ʻia e hana i kahi puʻu platelet e like me ka puʻu.Piʻi mālie ka puʻu a hui pū me nā leukocytes e hana i kahi thrombus keʻokeʻo.ʻOi aku ka nui o nā leukocytes i pili i kona ʻili.Ke holo mālie nei ke kahe o ke koko, hoʻāla ʻia ka ʻōnaehana coagulation, a ʻo ka nui o ka fibrin e hoʻokumu i kahi ʻano pūnaewele, kahi e pahele ai i nā ʻāpana koko ʻulaʻula a me nā keʻokeʻo keʻokeʻo e hana i kahi thrombus hui pū.

2. Hoʻopaʻa koko

Ma hope o ka hoʻokumu ʻia ʻana o ka thrombus keʻokeʻo, puka ia i loko o ka lumen vascular, e hoʻolohi i ke kahe ʻana o ke koko ma hope a ʻike ʻia he puahiohio, a ua hoʻokumu ʻia kahi puʻu platelet hou ma ka puahiohio.ʻO Trabeculae, he ʻano like me ke koʻa, he nui nā leukocytes i hoʻopili ʻia ma ko lākou ʻili.

Ke holo mālie nei ke kahe o ke koko ma waena o nā trabeculae, hoʻāla ʻia ka ʻōnaehana coagulation, a piʻi mālie ka neʻe ʻana o nā kumu coagulation kūloko a me nā platelet platelet, e hana ana a hoʻopili ʻia i loko o kahi ʻano mesh ma waena o nā trabeculae.Keʻokeʻo a me ke keʻokeʻo, corrugated hui pū ʻia i ke kino o ka thrombus.

Hoʻonui mālie ʻia ka thrombus hui ʻia a hoʻonui ʻia i ke ala o ke kahe ʻana o ke koko, a ma hope ua paʻa loa i ka lumen moku koko, e hoʻōki ai ke kahe ʻana o ke koko.