Ua hoʻolālā nā mea noiʻi ma ke Kulanui o Monash i kahi antibody hou e hiki ke kāohi i kahi protein kūikawā i loko o ke koko e pale ai i ka thrombosis me ka ʻole o nā hopena ʻaoʻao.Hiki i kēia antibody ke pale i ka thrombosis pathological, hiki ke hōʻeha i ka puʻuwai a me ka hahau ʻana me ka ʻole o ka hoʻopili ʻana i ke koko maʻamau.

ʻO ka hōʻeha puʻuwai a me ka hahau ʻana ke kumu nui o ka make a me ka maʻi maʻi ma ka honua holoʻokoʻa.Hiki i nā lāʻau lapaʻau antithrombotic (anticoagulant) i kēia manawa ke hoʻopilikia i ke koko koʻikoʻi no ka mea ke keʻakeʻa nei lākou i ke kahe koko maʻamau.ʻEhā hapalima o nā maʻi e loaʻa ana i ka lāʻau antiplatelet e loaʻa mau ana nā hanana cardiovascular.

No laila, ʻaʻole hiki ke hoʻohana ʻia nā lāʻau antiplatelet i kēia manawa i ka nui.No laila, hoʻopōʻino ka hana lapaʻau, a pono e hoʻolālā hou ʻia nā lāʻau e hiki mai ana.

ʻO ke ʻano noiʻi ʻo ka hoʻoholo mua ʻana i ka ʻokoʻa olaola ma waena o ka coagulation maʻamau a me ka coagulation pathological, a ʻike ʻia ʻo von Willebrand factor (VWF) e hoʻololi i kona mau waiwai ke hoʻokumu ʻia ka thrombus pōʻino.Ua hoʻolālā ka haʻawina i kahi antibody e ʻike a paʻa wale i kēia ʻano pathological o VWF, no ka mea, hana wale ia i ka wā e lilo ai ke koko.

Ua nānā ka haʻawina i nā hiʻohiʻona o nā antibodies anti-VWF i kēia manawa a hoʻoholo i nā hiʻohiʻona maikaʻi loa o kēlā me kēia antibody e hoʻopaʻa a hoʻopaʻa iā VWF ma lalo o nā kūlana coagulation pathological.I ka loaʻa ʻole o nā hopena ʻino, ua hui mua ʻia kēia mau antibodies i loko o kahi ʻano koko hou e pale ai i kēia mau pilikia.

Ke kū nei nā kauka lapaʻau i kahi kaulike maʻalahi ma waena o ka lāʻau lapaʻau a me nā hopena ʻaoʻao koko.Hoʻolālā kūikawā ʻia ka antibody engineered a ʻaʻole e hoʻopilikia i ka coagulation koko maʻamau, no laila ke manaʻolana ʻia e hiki ke hoʻohana i ka nui a ʻoi aku ka maikaʻi ma mua o nā lāʻau lapaʻau.

Ua mālama ʻia kēia haʻawina in vitro me nā laʻana koko kanaka.ʻO ka hana aʻe, ʻo ia ka hoʻāʻo ʻana i ka pono o ka antibody i loko o kahi ʻano holoholona liʻiliʻi e hoʻomaopopo i ka hana ʻana i loko o kahi ʻōnaehana ola paʻakikī e like me kā mākou.

Nānā: Thomas Hoefer et al.ʻO ka huli ʻana i ka shear gradient i hoʻāla ʻia ʻo von Willebrand factor e ka novel single-chain antibody A1 e hōʻemi ana i ka hoʻokumu ʻana o ka thrombus occlusive in vitro, Haematologica (2020).