ʻAʻole loaʻa ka coagulation koko inā maikaʻi a ʻino paha.Loaʻa i ka coagulation koko ka manawa maʻamau.Inā wikiwiki a lohi paha, e pōʻino ai ke kino o ke kanaka.

Aia ke koko coagulation i loko o kekahi ʻano maʻamau, i ʻole e hoʻokahe koko a hoʻokumu ʻia ka thrombus i loko o ke kino kanaka.Inā ʻoi aku ka wikiwiki o ka coagulation o ke koko, ʻo ia ka mea maʻamau e hōʻike ana aia ke kino o ke kanaka i kahi kūlana hypercoagulable, a ʻo nā maʻi cardiovascular a me nā maʻi cerebrovascular e hiki mai ana, e like me ka cerebral infarction a me ka Myocardial infarction, ka thrombosis venous haʻahaʻa a me nā maʻi ʻē aʻe.Inā lohi loa ke koko o ka mea maʻi, hiki ke loaʻa ka coagulation dysfunction, prone i nā maʻi koko, e like me ka hemophilia, a ma nā hihia koʻikoʻi, e waiho ʻia nā deformities hui a me nā hopena ʻino ʻē aʻe.

ʻO ka hana thrombin maikaʻi e hōʻike ana e hana maikaʻi ana nā platelets a olakino maikaʻi.ʻO ka coagulation e pili ana i ke kaʻina o ka hoʻololi ʻana o ke koko mai kahi moku e kahe ana i kahi kūlana gel, a ʻo kona ʻano kumu ke ʻano o ka hoʻololi ʻana i ka fibrinogen soluble i ka fibrinogen insoluble i loko o ka plasma.Ma ke ʻano haiki, i ka wā e pōʻino ai nā kīʻaha koko, hoʻopuka ke kino i nā mea coagulation, e hoʻāla ʻia e hana i ka thrombin, ka mea e hoʻohuli ai i ka fibrinogen i fibrin, a laila e hoʻoikaika i ka coagulation koko.Hoʻokomo pū ka coagulation i ka hana platelet.

ʻO ka noʻonoʻo ʻana inā maikaʻi ka coagulation a ʻaʻole paha ma o ka hoʻāʻo ʻana i ke koko a me nā hoʻokolohua.ʻO ka maʻi coagulation e pili ana i nā pilikia me nā kumu coagulation, hoʻemi ʻia a i ʻole ka hana ʻino, a me kahi ʻano o nā hōʻailona koko.Hiki ke kahe koko, a ʻike ʻia ka purpura, ecchymosis, epistaxis, bleeding gums, a me ka hematuria ma ka ʻili a me ka mucous membranes.Ma hope o ka trauma a i ʻole ka ʻoki ʻana, piʻi ka nui o ke koko a hiki ke hoʻolōʻihi ʻia ka manawa koko.Ma o ka ʻike ʻana i ka manawa prothrombin, ka manawa prothrombin i hoʻāla ʻia a me nā mea ʻē aʻe, ʻike ʻia ʻaʻole maikaʻi ka hana coagulation, a pono e wehewehe ʻia ke kumu o ka maʻi.