ʻO ke koʻikoʻi o ka hōʻike PT APTT FIB i nā maʻi hepatitis B


Mea kākau: Hope   

ʻO ke kaʻina hana coagulation he wailele-type protein enzymatic hydrolysis kaʻina e pili ana ma kahi o 20 mau mea, ʻo ka hapa nui o ia mau glycoproteins plasma synthesized e ke ake, no laila ke hana nui nei ke ake i ke kaʻina hemostasis i ke kino.ʻO ke koko he hōʻailona maʻamau o ka maʻi ate (maʻi ate), ʻoi aku ka nui o nā poʻe maʻi, a ʻo kekahi o nā kumu nui o ka make.

ʻO ka ate kahi wahi no ka synthesizing i nā ʻano coagulation like ʻole, a hiki ke synthesize a inactivate fibrin lysates a me nā mea antifibrinolytic, a pāʻani i kahi kuleana hoʻoponopono i ka mālama ʻana i ke koena ikaika o ka coagulation a me ka ʻōnaehana anticoagulation.ʻO kaʻikeʻana i nā helu helu coagulation koko i nā poʻe maʻi me ka maʻi hepa B ua hōʻikeʻiaʻaʻole heʻokoʻa nui ma ka PTAPTT i nā maʻi me ka maʻi hepa B maʻamau i hoʻohālikelikeʻia me ka pūʻulu hoʻomalu maʻamau (P>0.05), akā he nui kaʻokoʻa ma FIB (P<0.05). ).Nui nā ʻokoʻa ma PT, APTT, a me FIB ma waena o ka hui hepatitis B koʻikoʻi a me ka pūʻulu hoʻomalu maʻamau (P<005P<0.01), i hōʻoia i ka hoʻopili maikaʻi ʻana o ke koʻikoʻi o ka hepatitis B me ka hoʻohaʻahaʻa ʻana i nā pae kumu coagulation koko.

Ka nānā 'ana i nā kumu o nā hopena i luna:

1. Ma waho o ka helu IV (Ca *) a me ka cytoplasm, hoʻohui ʻia nā mea coagulation plasma ʻē aʻe i loko o ke ake;ʻO nā mea anticoagulation (nā mea hoʻopiʻi coagulation) e like me ATIPC, 2-MaI-AT, a me nā mea'ē aʻe i hoʻohui pūʻia e ke ake.ka hoʻopili pūnaewele.Ke hoʻopōʻino ʻia nā ʻōpū o ke akepaʻa a i ʻole necrotic i nā degere like ʻole, hiki i ka hiki o ke ake ke hoʻohui i nā mea coagulation a me nā mea anti-coagulation e hoʻemi ʻia, a hoʻemi ʻia nā pae plasma o kēia mau mea, e hopena i nā mea pale i ka mīkini coagulation.He hōʻike hōʻike ʻo PT i ka ʻōnaehana coagulation extrinsic, hiki ke hōʻike i ka pae, hana a me ka hana o ka coagulation factor IV VX i loko o ka plasma.ʻO ka emiʻana o nā mea i luna a iʻole nā ​​hoʻololi i kā lākou mau hana a me nā hana i lilo i hoʻokahi o nā kumu no ka lōʻihi o ka PT i nā maʻi me ka maʻi hepatitis B cirrhosis a me ka hepatitis B koʻikoʻi. nā mea i loko o ke ake.

2. Ma ka ʻaoʻao ʻē aʻe, me ka hōʻino ʻana o nā puʻupaʻa a me ka hāʻule ʻole o ka ate i nā maʻi hepatitis B, piʻi ka pae o ka plasmin i ka plasma i kēia manawa.ʻAʻole hiki i ka Plasmin ke hoʻokahe wale i ka nui o ka fibrin, fibrinogen a me nā mea coagulation he nui e like me ke aʻo kumu, XXX, VVII,, a me nā mea'ē aʻe, akā e hoʻopau pū i ka nui o nā mea anti-coagulation e like me ATPC a pela aku.No laila, me ka hohonu o ka maʻi, ua hoʻolōʻihi ʻia ka APTT a ua emi nui ka FIB i nā maʻi hepatitis B.

I ka hopena, ʻo ka ʻike ʻana i nā helu coagulation e like me PTAPTTFIB he koʻikoʻi koʻikoʻi koʻikoʻi koʻikoʻi no ka hoʻoponopono ʻana i ke kūlana o nā maʻi me ka maʻi hepatitis B mau loa, a he ʻano ʻike makaʻala a hilinaʻi.