Hiki ke ʻike ʻia he koʻikoʻi ka nānā ʻana o D-Dimer e pili ana i ka hoʻopiʻi ʻana i ka holomua o COVID-19, no laila pehea ke ʻano o ia i nā maʻi ʻē aʻe?

1. ʻO ka thromboembolism

Ua hoʻohana nui ʻia ʻo D-Dimer i nā maʻi pili i ka venous thromboembolism (VTE), e like me ka thrombosis hohonu hohonu (DVT) a me ka pulmonary embolism (PE).Hiki i ka ho'āʻo D-Dimer maikaʻi ke hoʻoholo i ka DVT, a hiki ke hoʻohana ʻia ka ʻike D-Dimer e wānana i ka helu hoʻi o VTE.Ua ʻike ʻia ka haʻawina ʻo ka lākiō pōʻino o ka hoʻi hou ʻana o VTE i ka heluna kanaka me ke kiʻekiʻe kiʻekiʻe he 4.1 mau manawa o ka heluna kanaka me ka ʻike maʻamau.

ʻO D-Dimer kekahi o nā hōʻailona ʻike o PE.He kiʻekiʻe loa kona waiwai wānana maikaʻi ʻole, a ʻo kona koʻikoʻi ke kāpae ʻana i ka embolism pulmonary acute, ʻoi aku ka nui o nā maʻi me ka kānalua haʻahaʻa.No laila, no nā poʻe maʻi i manaʻo ʻia he embolism pulmonary acute, pono e hui pū ʻia ka ultrasonography o nā veins hohonu o nā ʻaoʻao haʻahaʻa a me ka hoʻokolokolo D-Dimer.

2. Hoʻolaha ʻia ka coagulation intravascular

ʻO ka Disseminated intravascular coagulation (DIC) kahi maʻi maʻi i hōʻike ʻia e ka hemorrhage a me ka hemahema microcirculatory ma muli o nā maʻi he nui.ʻO ke kaʻina hana e pili ana i nā ʻōnaehana he nui e like me ka coagulation, anticoagulation, a me ka fibrinolysis.Ua hoʻonuiʻia ka D-Dimer i ka wā mua o ka hoʻokumuʻana o DIC, a ua hoʻomauʻia ka hoʻonuiʻana o kona manaʻo ma mua o 10-fold i ka holomua o ka maʻi.No laila, hiki ke hoʻohana ʻia ʻo D-Dimer e like me kekahi o nā hōʻailona nui no ka ʻike mua a me ka nānā ʻana i ke kūlana o DIC.

3. ʻAotic dissection

Ua kuhikuhi ʻo "Chinese expert consensus on the diagnostic and treatment of aortic dissection" ʻo D-Dimer, ma ke ʻano he hoʻokolohua maʻamau no ka ʻokiʻoki aortic (AD), he mea koʻikoʻi loa ia no ka ʻike ʻana a me ka ʻokoʻa ʻokoʻa o ka dissection.Ke piʻi wikiwiki ka D-Dimer o ka mea maʻi, hiki ke ʻike ʻia ke piʻi ʻana o AD.I loko o 24 mau hola o ka hoʻomaka ʻana, i ka hiki ʻana o D-Dimer i ka waiwai koʻikoʻi o 500 µg/L, ʻo 100% kona naʻau no ka hoʻomaʻamaʻa ʻana i ka maʻi AD, a ʻo kona kikoʻī ʻo 67%, no laila hiki ke hoʻohana ʻia ma ke ʻano he kuhikuhi hoʻokaʻawale no ka ʻike ʻana o ka maʻi. Acute AD.

4. Atherosclerotic Cardiovascular Disease

ʻO ka maʻi cardiovascular Atherosclerotic kahi maʻi puʻuwai i hoʻokumu ʻia e ka arteriosclerotic plaque, e komo pū ana me ST-segment elevation acute myocardial infarction, non-ST-segment elevation acute myocardial infarction, a me unstable angina.Ma hope o ka haki ʻana o ka plaque, kahe ka necrotic core material i loko o ka plaque, e hoʻoulu ai i nā ʻāpana kahe o ke koko, ka hoʻoulu ʻana o ka ʻōnaehana coagulation, a me ka hoʻonui ʻana o D-Dimer.Hiki i nā poʻe maʻi maʻi naʻau coronary me D-Dimer kiʻekiʻe ke wānana i kahi pilikia kiʻekiʻe o ka AMI a hiki ke hoʻohana ʻia ma ke ʻano he hōʻailona e nānā i ke kūlana o ACS.

5. Thrombolytic therapy

Ua ʻike ʻia ka haʻawina a Latter e hiki ke hoʻonui i nā lāʻau thrombolytic like ʻole i ka D-Dimer, a hiki ke hoʻohana ʻia kona hoʻololi ʻana ma mua a ma hope o ka thrombolysis i mea hōʻailona no ka hoʻokolokolo ʻana i ka thrombolytic therapy.Ua hoʻonui koke ʻia kāna ʻike i ka waiwai kiʻekiʻe ma hope o ka thrombolysis, a hāʻule i hope i ka manawa pōkole me ka hoʻomaikaʻi nui ʻana i nā hōʻailona lapaʻau, e hōʻike ana i ka maikaʻi o ka mālama ʻana.

- Ua hoʻonui nui ʻia ke kiʻekiʻe o D-Dimer i ka hola 1 a i 6 mau hola ma hope o ka thrombolysis no ka infarction myocardial acute a me ka infarction cerebral.
- I ka wā o ka thrombolysis DVT, hiki mai ka piko D-Dimer ma 24 mau hola a ma hope paha