A ƙarƙashin yanayin ilimin lissafin jiki, tsarin guda biyu na haɗin jini da anticoagulation a cikin jiki suna kula da ma'auni mai ƙarfi don kiyaye jinin da ke gudana a cikin jini.Idan ma'auni ya kasance ba daidai ba, tsarin rigakafi yana da yawa kuma yanayin zubar da jini yana iya faruwa, kuma tsarin coagulation yana da yawa kuma thrombosis yana da wuyar faruwa.Tsarin fibrinolysis yana taka muhimmiyar rawa a cikin thrombolysis.A yau za mu yi magana game da sauran alamomi guda biyu na tsarin fibrinolysis, D-dimer da FDP, don cikakken fahimtar hemostasis da thrombin ya haifar zuwa thrombus wanda fibrinolysis ya fara.Juyin Halitta.Bayar da mahimman bayanai na asibiti game da thrombosis na marasa lafiya da aikin coagulation.
D-dimer takamaiman samfuri ne na lalata da fibrin monomer ke haɗe da haɗin kai ta hanyar factor XIII mai kunnawa sannan kuma plasmin ya samar da ruwa.D-dimer an samo shi ne daga ɗigon fibrin mai haɗe-haɗe wanda ya narkar da plasmin.D-dimer mai girma yana nuna kasancewar hyperfibrinolysis na biyu (kamar DIC).FDP shine kalmar gama gari don samfuran lalata da aka samar bayan fibrin ko fibrinogen ya rushe ƙarƙashin aikin plasmin da aka samar yayin hyperfibrinolysis.FDP ya hada da fibrinogen (Fg) da fibrin monomer (FM) kayayyakin (FgDPs), da kuma kayayyakin rage radadin fibrin (FbDPs), daga cikinsu FbDPs sun hada da D-dimers da sauran gutsuttsura, kuma matakansu ya karu High yana nuna cewa jiki yana karuwa. Ayyukan fibrinolytic shine hyperactive (fibrinolysis na farko ko fibrinolysis na biyu)
【Misali】
An kwantar da wani namiji mai matsakaicin shekaru a asibiti kuma sakamakon gwajin da aka yi masa na toshewar jini kamar haka.
| Abu | Sakamako | Rage Magana |
| PT | 13.2 | 10-14s |
| APTT | 28.7 | 22-32s |
| TT | 15.4 | 14-21s |
| FIB | 3.2 | 1.8-3.5g/l |
| DD | 40.82 | 0-0.55mg/I FEU |
| FDP | 3.8 | 0-5mg/l |
| AT-III | 112 | 75-125% |
Abubuwan guda hudu na coagulation duk sun kasance marasa kyau, D-dimer yana da kyau, kuma FDP mara kyau, kuma sakamakon ya saba wa juna.Da farko da ake zargin cewa tasirin ƙugiya ne, an sake gwada samfurin ta ainihin maɓalli da gwajin dilution na 1:10, sakamakon ya kasance kamar haka:
| Abu | Na asali | 1:10 dilution | Rage Magana |
| DD | 38.45 | 11.12 | 0-0.55mg/I FEU |
| FDP | 3.4 | Ƙasa da ƙananan iyaka | 0-5mg/l |
Ana iya gani daga dilution cewa sakamakon FDP ya kamata ya zama al'ada, kuma D-dimer ba layi ba ne bayan dilution, kuma ana zargin tsangwama.A ware hemolysis, lipemia, da jaundice daga matsayin samfurin.Saboda sakamakon rashin daidaituwa na dilution, irin waɗannan lokuta na iya faruwa a cikin tsoma baki tare da kwayoyin heterophilic ko abubuwan rheumatoid.Bincika tarihin likita na majiyyaci kuma nemo tarihin cututtukan cututtuka na rheumatoid.Laboratory Sakamakon gwajin fa'idar RF ya yi girma sosai.Bayan sadarwa tare da asibitin, an yi magana da mai haƙuri kuma ya ba da rahoto.A cikin bayanan da aka biyo baya, mai haƙuri ba shi da alamun cututtukan da ke da alaƙa da thrombus kuma an yi la'akari da shi a matsayin shari'ar ƙarya na D-dimer.
【Takaita】
D-dimer alama ce mai mahimmanci na keɓancewar thrombosis mara kyau.Yana da babban hankali, amma ƙayyadaddun ƙayyadaddun daidai zai zama rauni.Har ila yau, akwai wani kaso na ƙimar gaskiya.Haɗuwa da D-dimer da FDP na iya rage wani ɓangare na D- Don ƙimar ƙaryar dimer, lokacin da sakamakon binciken ya nuna cewa D-dimer ≥ FDP, ana iya yanke hukunci masu zuwa akan sakamakon gwajin:
1. Idan darajar ta yi ƙasa (
2. Idan sakamakon yana da ƙima mai girma (> Ƙimar Yankewa), bincika abubuwan da ke tasiri, za a iya samun abubuwan tsangwama.Ana ba da shawarar yin gwajin dilution da yawa.Idan sakamakon yana kan layi, tabbataccen gaskiya yana iya yiwuwa.Idan ba layi ba ne, tabbataccen ƙarya.Hakanan zaka iya amfani da reagent na biyu don tabbatarwa da sadarwa tare da asibitin cikin lokaci.
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