D-dimer yawanci ana amfani dashi azaman ɗaya daga cikin mahimman abubuwan da ake zargi na PTE da DVT a cikin aikin asibiti.Ta yaya abin ya kasance?

Plasma D-dimer takamaiman samfur ne na lalata da plasmin hydrolysis ke samarwa bayan an haɗa fibrin monomer ta hanyar kunna factor XIII.Yana da takamaiman alamar tsarin fibrinolysis.D-dimers an samo su ne daga ɗigon fibrin da aka haɗa ta hanyar plasmin.Muddin akwai thrombosis mai aiki da aikin fibrinolytic a cikin tasoshin jini na jiki, D-dimer zai karu.Ƙunƙarar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta , tiyata , ciwon daji , ƙwayar cuta ta intravascular , kamuwa da cuta da necrosis na nama zai iya haifar da haɓakar D-dimer .Musamman ga tsofaffi da marasa lafiya a asibiti, saboda ƙwayoyin cuta da sauran cututtuka, yana da sauƙi don haifar da rashin daidaituwa na jini da kuma haifar da karuwar D-dimer.

D-dimer yawanci yana nuna aikin fibrinolytic.Ƙara ko tabbatacce da aka gani a cikin hyperfibrinolysis na biyu, irin su hypercoagulable jihar, watsawa intravascular coagulation, renal cuta, dashe dashen gabobin, thrombolytic far, da dai sauransu Ƙaddamar da manyan dalilai na fibrinolytic tsarin ne mai girma muhimmanci ga ganewar asali da kuma lura da cututtuka na tsarin fibrinolytic (kamar DIC, daban-daban thrombus) da cututtuka da suka shafi tsarin fibrinolytic (irin su ciwace-ciwacen ƙwayoyi, ciwon ciki), da kuma kula da maganin thrombolytic.

Matsakaicin matakan D-dimer, samfurin lalata fibrin, yana nuna raguwar fibrin akai-akai a cikin vivo.Sabili da haka, D-dimer fibrous shine maɓalli mai mahimmanci na thrombosis mai zurfi (DVT), embolism na huhu (PE), watsawar intravascular coagulation (DIC).

Yawancin cututtuka suna haifar da kunna tsarin coagulation da / ko tsarin fibrinolytic a cikin jiki, wanda ya haifar da karuwa a matakin D-dimer, kuma wannan kunnawa yana da alaƙa da mataki, tsanani da kuma maganin cutar, don haka a cikin wadannan cututtuka. Gano matakin D-dimer za a iya amfani da shi azaman alamar kimantawa don tsara cututtuka, tsinkaye da jagorar jiyya.

Aikace-aikacen D-dimer a cikin thrombosis mai zurfi

Tun da Wilson et al.na farko da aka yi amfani da kayan lalata fibrin don gano ciwon huhu a cikin 1971, gano D-dimer ya taka rawar gani sosai wajen gano cutar ta huhu.Tare da wasu hanyoyin ganowa sosai, ƙimar Jikin D-dimer mara kyau yana da kyakkyawan sakamako mara kyau ga cututtukan huhu, kuma ƙimar sa shine 0.99.Wani mummunan sakamako na iya yin watsi da embolism na huhu, ta haka ne ya rage gwaje-gwaje masu banƙyama, irin su duban iska da kuma angiography na huhu;kauce wa maganin rigakafi na makanta.D - Matsakaicin dimer yana da alaƙa da wurin da thrombus yake, tare da mafi girma a cikin manyan rassan huhu na huhu da ƙananan ƙwayoyin cuta a cikin ƙananan rassan.

D-dimers plasma mara kyau suna yin watsi da yiwuwar DVT.Angiography ya tabbatar da DVT ya kasance 100% tabbatacce ga D-dimer.Ana iya amfani da shi don maganin thrombolytic da heparin anticoagulation jagora da lura da inganci.

D-dimer na iya nuna canje-canje a girman thrombus.Idan abun ciki ya sake karuwa, yana nuna sake dawowa na thrombus;a lokacin lokacin jiyya, yana ci gaba da girma, kuma girman thrombus ba ya canzawa, yana nuna cewa maganin ba shi da amfani.