1. Aikace-aikacen D-Dimer a cikin marasa lafiya tare da COVID-19: A ma'ana, COVID-19 cuta ce ta thrombotic da cututtukan rigakafi ke haifar da su, tare da amsa kumburin kumburi da microthrombosis a cikin huhu.An ba da rahoton cewa fiye da kashi 20% na marasa lafiya tare da VTE a cikin maganganun asibiti na COVID-19.

• Matakan D-Dimer akan shigar da kansa yayi annabta mutuwar asibiti da kansa kuma an tantance marasa lafiya masu haɗarin gaske.A halin yanzu, D-dimer ya zama ɗaya daga cikin mahimman abubuwan dubawa ga marasa lafiya tare da COVID-19 lokacin da aka kwantar da su a asibiti.

Ana iya amfani da D-Dimer don jagora ko fara maganin rigakafin heparin a cikin marasa lafiya da COVID-19.An ba da rahoton cewa a cikin marasa lafiya tare da D-Dimer ≥ 6-7 sau da yawa mafi girman iyakar ma'anar, ƙaddamar da maganin heparin zai iya inganta sakamakon haƙuri.

Ana iya amfani da saka idanu mai ƙarfi na D-Dimer don tantance faruwar VTE a cikin marasa lafiya da COVID-19.

• Sa ido D-Dimer, wanda za a iya amfani da shi don tantance sakamakon COVID-19.

• Kulawa da D-Dimer, lokacin da maganin cutar ya fuskanci shawara, shin D-Dimer zai iya ba da wasu bayanan tunani?Akwai gwaje-gwajen asibiti da yawa a ƙasashen waje da ake gani.

2. D-Dimer dynamic monitoring yana annabta samuwar VTE:

Kamar yadda aka ambata a sama, rabin rayuwar D-Dimer shine 7-8h.Daidai saboda wannan fasalin ne D-Dimer na iya sa ido a hankali da hasashen samuwar VTE.Don yanayin hypercoagulable na wucin gadi ko microthrombosis, D-Dimer zai ƙaru kaɗan sannan ya ragu da sauri.Lokacin da aka sami ci gaba da samuwar thrombus a cikin jiki, D-Dimer a cikin jiki zai ci gaba da tashi, yana nuna kololuwa mai tsayi kamar tsayi.Ga mutanen da ke da ƙwayar cuta mai yawa, irin su m da tsanani lokuta, marasa lafiya na baya-bayan nan, da dai sauransu, idan matakin D-Dimer ya karu da sauri, yi hankali ga yiwuwar thrombosis.A cikin "Yarjejeniyar Yarjejeniya a kan allo da lura da zurfin jijiya a cikin cutar orthopedic ya kamata a kiyaye canje-canje na D-Dimer kowane 48 hours.Ya kamata a yi gwajin hoto a kan lokaci don bincika DVT.

3. D-Dimer a matsayin alamar tsinkaya ga cututtuka daban-daban:

Saboda kusancin kusanci tsakanin tsarin coagulation da kumburi, rauni na endothelial, da dai sauransu, ana kuma lura da haɓakar D-Dimer a wasu cututtukan da ba su da thrombotic kamar kamuwa da cuta, tiyata ko rauni, gazawar zuciya, da ciwace-ciwacen daji.Bincike ya gano cewa mafi yawan rashin hasashe na waɗannan cututtuka shine thrombosis, DIC, da dai sauransu. Yawancin waɗannan rikice-rikice sune cututtuka ko jihohin da ke haifar da hawan D-Dimer.Sabili da haka, ana iya amfani da D-Dimer azaman maƙasudin ƙima mai faɗi da ƙima don cututtuka.

• Ga marasa lafiya da ciwon daji, yawancin bincike sun gano cewa shekarun rayuwa na 1-3 na marasa lafiya marasa lafiya tare da D-Dimer mai girma yana da mahimmanci fiye da na marasa lafiya na D-Dimer na al'ada.Za a iya amfani da D-Dimer a matsayin mai nuna alama don ƙididdige ƙididdiga na marasa lafiya na ciwon daji.

• Ga marasa lafiya na VTE, bincike da yawa sun tabbatar da cewa marasa lafiya na D-Dimer-tabbatacce tare da VTE suna da haɗarin 2-3 mafi girma na sake dawowar thrombus na gaba yayin anticoagulation fiye da marasa lafiya marasa lafiya.Wani bincike-bincike wanda ya hada da nazarin 7 tare da jimillar batutuwa na 1818 ya nuna cewa, D-Dimer mara kyau yana daya daga cikin manyan abubuwan da ke haifar da sake dawowar thrombus a cikin marasa lafiya na VTE, kuma D-Dimer an haɗa shi a cikin nau'i-nau'i na haɗarin haɗari na sake dawowa VTE.

• Don maye gurbin bawul na inji (MHVR) marasa lafiya, binciken da aka yi na dogon lokaci na batutuwa na 618 ya nuna cewa haɗarin abubuwan da suka faru a cikin marasa lafiya tare da matakan D-Dimer mara kyau a lokacin warfarin bayan MHVR ya kasance kusan sau 5 na marasa lafiya na al'ada.Binciken daidaitawa da yawa ya tabbatar da cewa matakin D-Dimer ya kasance mai tsinkaya mai zaman kansa na thrombotic ko abubuwan da ke faruwa na zuciya a lokacin maganin rigakafi.

• Ga marasa lafiya tare da fibrillation na atrial (AF), D-Dimer na iya yin la'akari da abubuwan da suka faru na thrombotic da abubuwan da ke faruwa na zuciya da jijiyoyin jini a cikin maganin rigakafi na baki.Wani bincike mai yiwuwa na marasa lafiya 269 tare da fibrillation na atrial da aka biyo baya na kimanin shekaru 2 ya nuna cewa a lokacin maganin rigakafi na baka, kimanin kashi 23% na marasa lafiya tare da INR sun kai ga maƙasudin sun nuna matakan D-Dimer mara kyau, yayin da marasa lafiya da ƙananan matakan D-Dimer suka ci gaba da hadarin thrombotic. abubuwan da suka faru da kuma abubuwan da ke tattare da cututtukan zuciya sun kasance 15.8 da 7.64 sau, bi da bi, na marasa lafiya tare da matakan D-Dimer na al'ada.

• Ga waɗannan takamaiman cututtuka ko takamaiman marasa lafiya, D-Dimer mai ɗaukaka ko ci gaba yana nuna rashin hasashe ko tabarbarewar cutar.

4. Aikace-aikace na D-Dimer a cikin maganin anticoagulation na baka:

• D-Dimer yana ƙayyade tsawon lokacin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin rigakafi.Ko da kuwa ko NOAC ne ko VKA, jagororin ƙasa da ƙasa masu dacewa sun ba da shawarar cewa ya kamata a yanke shawarar maganin rigakafi na tsawon lokaci gwargwadon haɗarin zubar jini a cikin wata na uku na maganin rigakafin cutar, kuma D-Dimer na iya ba da bayanan mutum ɗaya don wannan.

• D-Dimer yana jagorantar daidaita ƙarfin maganin ciwon ciki na baka: Warfarin da sababbin magungunan maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin rigakafi.da kunna tsarin fibrinolytic, ta haka a kaikaice rage matakin D-Dimer.Sakamakon gwaji ya nuna cewa D-Dimer-guided anticoagulation a cikin marasa lafiya yadda ya kamata ya rage yawan abubuwan da suka faru.