Yanayi Don Thrombosis


Marubuci: Magaji   

A cikin zuciya mai rai ko tasoshin jini, wasu abubuwan da ke cikin jini suna yin coagulation ko coagulation don samar da wani taro mai ƙarfi, wanda ake kira thrombosis.Ƙaƙƙarfan taro wanda ke samuwa ana kiransa thrombus.

A cikin yanayin al'ada, akwai tsarin coagulation da tsarin rigakafi (tsarin fibrinolysis, ko tsarin fibrinolysis a takaice) a cikin jini, kuma ana kiyaye daidaito mai ƙarfi tsakanin su biyun, don tabbatar da cewa jini yana yawo a cikin tsarin zuciya da jijiyoyin jini a cikin ruwa. jiharkwarara kwarara

Abubuwan da ke haifar da coagulation a cikin jini suna ci gaba da kunnawa, kuma ana samar da ƙaramin adadin thrombin don samar da ƙaramin adadin fibrin, wanda aka ajiye akan intima na jirgin jini, sannan narkar da tsarin fibrinolytic mai kunnawa.A lokaci guda, abubuwan da ke kunna coagulation suma ana ci gaba da phagocytosed kuma suna share su ta tsarin macrophage na mononuclear.

Duk da haka, a karkashin yanayin cututtuka, ma'auni mai ƙarfi tsakanin coagulation da anticoagulation yana rushewa, aikin tsarin haɗin gwiwar yana da rinjaye, kuma jini yana haɗuwa a cikin tsarin zuciya na zuciya don samar da thrombus.

Thrombosis yawanci yana da halaye guda uku masu zuwa:

1. Raunin intima na zuciya da jijiyoyin jini

Ƙunƙarar zuciya na al'ada da tasoshin jini ba su da kyau kuma suna santsi, kuma ƙwayoyin ƙwararrun ƙwanƙwasa suna iya hana mannewar platelet da anticoagulation.Lokacin da membrane na ciki ya lalace, ana iya kunna tsarin coagulation ta hanyoyi da yawa.

Intima na farko da ya lalace yana sakin ƙwayar coagulation na nama (coagulation factor III), wanda ke kunna tsarin coagulation na waje.
Na biyu, bayan da intima ya lalace, ƙwayoyin endothelial suna fuskantar lalacewa, necrosis, da zubarwa, suna fallasa ƙwayoyin collagen a ƙarƙashin endothelium, don haka kunna coagulation factor XII na tsarin coagulation na endogenous da kuma fara tsarin coagulation na endogenous.Bugu da ƙari, intima mai lalacewa ya zama m, wanda zai dace da ƙaddamar da platelet da mannewa.Bayan ɓarkewar platelet ɗin da ke mannewa, ana fitar da abubuwa iri-iri, kuma ana kunna tsarin haɗin gwiwa gabaɗaya, yana haifar da jini don yin coagulation kuma ya zama thrombus.
Daban-daban na jiki, sinadarai da ilimin halitta na iya haifar da lahani ga intima na zuciya, kamar endocarditis a cikin erysipelas alade, vasculitis na huhu a cikin ciwon huhu na bovine, equine parasitic arteritis, maimaita injections a cikin ɓangaren jijiya, Rauni da huda bangon jini. a lokacin tiyata.

2. Canje-canje a yanayin kwararar jini

Galibi yana nufin jinkirin kwararar jini, samuwar vortex da gushewar jini.
A karkashin yanayi na al'ada, adadin jini yana da sauri, kuma jajayen ƙwayoyin jini, platelets da sauran abubuwan da aka tattara suna tattara su a tsakiyar tashar jini, wanda ake kira axial flow;lokacin da adadin jinin ya ragu, ƙwayoyin jajayen jini da platelets za su gudana kusa da bangon jijiyar jini, wanda ake kira side flow, wanda ke ƙara thrombosis.hadarin da ya taso.
Jinin jini yana raguwa, kuma ƙwayoyin endothelial suna da mummunar hypoxic, suna haifar da lalacewa da necrosis na sel na endothelial, asarar aikin su na hadawa da sakin abubuwan da ke haifar da ciwon zuciya, da kuma bayyanar collagen, wanda ke kunna tsarin coagulation da ingantawa. thrombosis.
Jinkirin jini yana iya sanya thrombus da aka kafa cikin sauƙi don gyarawa a bangon tashar jini kuma ya ci gaba da karuwa.

Sabili da haka, thrombus sau da yawa yana faruwa a cikin jijiyoyi tare da jinkirin jini kuma yana da sauƙi ga igiyoyin ruwa (a venous valves).Gudun jinin aortic yana da sauri, kuma thrombus ba a cika gani ba.Bisa kididdigar da aka yi, abin da ya faru na jijiyar jini ya ninka sau 4 fiye da na thrombosis na arterial, kuma jijiyar jijiyar sau da yawa yakan faru a cikin ciwon zuciya, bayan tiyata ko a cikin dabbobi marasa lafiya kwance a cikin gida na dogon lokaci.
Saboda haka, yana da matukar muhimmanci a taimaka wa dabbobi marasa lafiya da suka dade suna kwance kuma bayan tiyata don yin wasu ayyukan da suka dace don hana thrombosis.
3. Canje-canje a cikin abubuwan jini.

Yawanci yana nufin ƙarar coagulation na jini.Kamar ƙonawa mai yawa, rashin ruwa, da sauransu don tattara jini, rauni mai tsanani, bayan haihuwa, da asarar jini mai tsanani bayan manyan ayyuka na iya ƙara yawan adadin platelet a cikin jini, ƙara dankon jini, da ƙara yawan abubuwan fibrinogen, thrombin da sauran abubuwan coagulation. a cikin plasma karuwa.Wadannan abubuwan zasu iya inganta thrombosis.

Takaitawa

Abubuwa uku da ke sama sukan kasance tare a cikin tsarin thrombosis kuma suna shafar juna, amma wani abu yana taka muhimmiyar rawa a matakai daban-daban na thrombosis.

Sabili da haka, a cikin aikin asibiti, yana yiwuwa a hana thrombosis ta hanyar fahimtar yanayin thrombosis daidai da ɗaukar matakan da suka dace daidai da ainihin halin da ake ciki.Irin wannan aikin tiyata ya kamata ya kula da aiki mai laushi, ya kamata a yi ƙoƙari don guje wa lalacewar jijiyoyin jini.Don allurar cikin jini na dogon lokaci, guje wa amfani da wuri ɗaya, da sauransu.