(1) D-dimar
A matsayin samfurin lalacewa na fibrin mai haɗin gwiwa, D-dimer alama ce ta gama gari wacce ke nuna kunnawar coagulation da hyperfibrinolysis na biyu.A cikin marasa lafiya da COVID-19, haɓakar matakan D-dimer alama ce mai mahimmanci don yiwuwar rikicewar coagulation.Matakan D-dimer suma suna da alaƙa da tsananin cutar, kuma marasa lafiya da ke da girman D-dimer akan shigar da su suna da mummunan hasashen.Sharuɗɗa daga Ƙungiyar Ƙasa ta Duniya na Thrombosis da Hemostasis (ISTH) sun ba da shawarar cewa D-dimer da aka ɗaukaka sosai (yawanci fiye da sau 3 ko 4 na babba na al'ada) na iya zama nuni ga asibiti a cikin marasa lafiya na COVID-19, bayan cire contraindications. Anticoagulation tare da prophylactic allurai na heparin low-molecular nauyi ya kamata a bai wa irin wannan marasa lafiya da wuri-wuri.Lokacin da D-dimer ya ci gaba da haɓaka kuma akwai babban zato na thrombosis venous ko microvascular embolism, ya kamata a yi la'akari da anticoagulation tare da maganin warkewa na heparin.

Kodayake girman D-dimer na iya ba da shawarar hyperfibrinolysis, haɓakar jini a cikin marasa lafiya na COVID-19 tare da ɗaukaka D-dimer ba sabon abu ba ne sai dai idan an ci gaba zuwa yanayin yanayin hypocoagulable na DIC, yana ba da shawarar cewa COVID-19 Tsarin fibrinolytic na -19 har yanzu an hana shi.Wani alamar da ke da alaƙa da fibrin, wato, canjin yanayin matakin FDP da matakin D-dimer sun kasance iri ɗaya ne.

 

(2) PT
Tsawon PT shima alama ce ta yiwuwar rikicewar coagulation a cikin marasa lafiya na COVID-19 kuma an nuna yana da alaƙa da rashin hangen nesa.A farkon matakin cutar coagulation a cikin COVID-19, marasa lafiya tare da PT yawanci al'ada ne ko kuma ba su da kyau, kuma PT mai tsayi a cikin lokacin hypercoagulable yawanci yana nuna kunnawa da amfani da abubuwan coagulation na waje, da kuma raguwar fibrin polymerization, don haka shi ma maganin rigakafi ne.daya daga cikin alamomin.Duk da haka, idan PT ya kara tsawo sosai, musamman ma lokacin da majiyyaci yana da bayyanar jini, yana nuna cewa rashin lafiyar coagulation ya shiga cikin ƙananan matakan coagulation, ko kuma mai haƙuri yana da rikitarwa ta hanyar rashin hanta, rashi bitamin K, maganin rigakafi, da dai sauransu. Ya kamata a yi la'akari da zubar jini na jini.Madadin magani.Wani abu na nunawa na coagulation, lokacin thromboplastin da aka kunna (APTT), yawanci ana kiyaye shi a matakin al'ada yayin lokacin hypercoagulable na rikice-rikice na coagulation, wanda za'a iya danganta shi da ƙara yawan amsawar factor VIII a cikin yanayin kumburi.

 

(3) Ƙididdigar platelet da gwajin aiki
Ko da yake kunna coagulation na iya haifar da rage yawan amfani da platelet, raguwar adadin platelet ba sabon abu bane a cikin marasa lafiya na COVID-19, wanda na iya zama alaƙa da haɓakar sakin thrombopoietin, IL-6, cytokines waɗanda ke haɓaka haɓakar platelet a cikin jihohin masu kumburi Don haka, ƙimar cikakkiyar ƙimar. Ƙididdigar platelet ba alama ce mai mahimmanci da ke nuna rashin lafiyar coagulation a cikin COVID-19 ba, kuma yana iya zama mafi mahimmanci a kula da canje-canjensa.Bugu da kari, raguwar adadin platelet yana da alaƙa sosai da rashin hasashe kuma yana ɗaya daga cikin alamun rigakafin rigakafi.Koyaya, lokacin da ƙididdigewa ya ragu sosai (misali, <50 × 109/L), kuma majiyyaci yana da bayyanar jini, yakamata a yi la’akari da ƙarin juzu'i na platelet.

Hakazalika da sakamakon binciken da aka yi a baya a cikin marasa lafiya tare da sepsis, in vitro platelet gwajin gwaje-gwaje a cikin marasa lafiya na COVID-19 tare da rikicewar coagulation yawanci suna haifar da ƙarancin sakamako, amma ainihin platelets a cikin marasa lafiya galibi ana kunna su, wanda yana iya kasancewa ga ƙananan aiki.Ana fara amfani da manyan platelets kuma ana cinye su ta hanyar tsarin coagulation, kuma aikin dangi na platelet a cikin wuraren da aka tattara yana da ƙasa.

 

(4) FIB
A matsayin furotin mai saurin lokaci, marasa lafiya tare da COVID-19 galibi suna da matakan girma na FIB a cikin matsanancin lokaci na kamuwa da cuta, wanda ba wai kawai yana da alaƙa da tsananin kumburi ba, amma haɓakar FIB kanta shima yana da haɗari ga thrombosis, don haka ana iya amfani da shi azaman COVID-19 Ɗaya daga cikin alamomin maganin rigakafi a cikin marasa lafiya.Duk da haka, lokacin da mai haƙuri ya sami raguwar ci gaba a cikin FIB, yana iya nuna cewa rashin lafiyar coagulation ya ci gaba zuwa mataki na hypocoagulable, ko kuma mai haƙuri yana da ciwon hanta mai tsanani, wanda yawanci yakan faru a ƙarshen mataki na cutar, lokacin da FIB <1.5 g. / L kuma tare da zub da jini, ya kamata a yi la'akari da jiko na FIB.