1. Lokacin Prothrombin (PT):

PT yana nufin lokacin da ake buƙata don canza prothrombin zuwa thrombin, yana haifar da haɗin jini na plasma, yana nuna aikin haɗin gwiwa na hanyar coagulation na waje.PT galibi ana ƙaddara ta matakan abubuwan coagulation I, II, V, VII, da X da hanta ta haɗa.Maɓalli mai mahimmanci na coagulation a cikin hanyar coagulation na waje shine factor VII, wanda ke samar da hadaddun FVIIa-TF tare da ƙwayar nama (TF)., wanda ke fara aikin coagulation na waje.PT na mata masu juna biyu na al'ada ya fi na mata marasa ciki.Lokacin da abubuwan X, V, II ko na suka ragu, PT na iya tsawaitawa.PT ba ya kula da rashin ƙwayar coagulation guda ɗaya.PT yana da tsayi sosai lokacin da ƙaddamarwar prothrombin ya faɗi ƙasa da 20% na matakin al'ada kuma abubuwan V, VII, da X sun faɗi ƙasa da 35% na matakin al'ada.PT ya tsawaita sosai ba tare da haifar da zubar da jini ba.Ana ganin gajeriyar lokacin prothrombin a lokacin daukar ciki a cikin cututtukan thromboembolic da jihohin hypercoagulable.Idan PT yana da 3 s fiye da kulawa na al'ada, ya kamata a yi la'akari da ganewar asali na DIC.

2. Lokacin Thrombin:

Lokacin Thrombin shine lokacin juyar da fibrinogen zuwa fibrin, wanda zai iya nuna inganci da adadin fibrinogen a cikin jini.An rage lokacin thrombin a cikin mata masu juna biyu na al'ada idan aka kwatanta da mata marasa ciki.Babu wani gagarumin canje-canje a lokacin thrombin a duk lokacin ciki.Hakanan lokacin thrombin shine ma'auni mai mahimmanci don samfuran lalata fibrin da canje-canje a cikin tsarin fibrinolytic.Ko da yake an rage lokacin thrombin a lokacin daukar ciki, sauye-sauye tsakanin lokutan ciki daban-daban ba su da mahimmanci, wanda kuma ya nuna cewa kunna tsarin fibrinolytic a cikin ciki na al'ada yana inganta., don daidaitawa da haɓaka aikin coagulation.Wang Li et al[6] sun gudanar da nazarin kwatance tsakanin mata masu juna biyu na yau da kullun da kuma mata marasa ciki.Sakamakon gwajin lokaci na thrombin na ƙungiyar mata masu juna biyu sun fi guntu fiye da na ƙungiyar kulawa da farkon da kuma na tsakiya na ciki, yana nuna cewa alamar lokaci na thrombin a cikin ƙungiyar masu ciki na ƙarshe ya fi na PT da kunna thromboplastin.Lokaci (lokacin thromboplastin da aka kunna, APTT) ya fi kulawa.

3. APTT:

Lokacin aiki na ɗan lokaci na thromboplastin ana amfani dashi galibi don gano canje-canje a cikin aikin coagulation na hanyar coagulation na ciki.A ƙarƙashin yanayin ilimin lissafin jiki, manyan abubuwan haɗin gwiwar da ke cikin hanyar haɗin kai na ciki sune XI, XII, VIII da VI, wanda coagulation factor XII shine muhimmin mahimmanci a wannan hanyar.XI da XII, prokallikrein da babban nauyin kwayoyin excitogen suna shiga cikin haɗin gwiwa lokaci na coagulation.Bayan kunna lokacin tuntuɓar, XI da XII ana kunna su a jere, ta haka za su fara hanyar haɗin gwiwa na endogenous.Rahoton wallafe-wallafen ya nuna cewa idan aka kwatanta da matan da ba su da juna biyu, lokacin da aka kunna thromboplastin a cikin al'ada na al'ada yana raguwa a duk lokacin da ake ciki, kuma na biyu da na uku na uku sun fi guntu fiye da na farkon matakin.Kodayake a cikin ciki na al'ada, abubuwan coagulation XII, VIII, X, da XI suna ƙaruwa daidai da haɓakar makonni na gestation a duk lokacin ciki, saboda coagulation factor XI bazai canza ba a cikin na biyu da na uku na ciki, duk aikin coagulation na endogenous A tsakiyar tsakiya. da kuma marigayi ciki, canje-canjen ba a bayyane suke ba.

4. Fibrinogen (Fg):

A matsayin glycoprotein, yana samar da peptide A da peptide B a ƙarƙashin thrombin hydrolysis, kuma a ƙarshe ya samar da fibrin da ba ya narkewa don dakatar da zubar jini.Fg yana taka muhimmiyar rawa a cikin tsarin tattara platelet.Lokacin da aka kunna platelets, fibrinogen receptor GP Ib/IIIa yana samuwa akan membrane, kuma ana samun tarin platelet ta hanyar haɗin Fg, kuma a ƙarshe an samu thrombus.Bugu da ƙari, a matsayin furotin mai saurin amsawa, karuwa a cikin ƙwayar plasma na Fg yana nuna cewa akwai wani abu mai kumburi a cikin jini, wanda zai iya rinjayar rheology na jini kuma shine babban mahimmanci na danko na plasma.Yana shiga kai tsaye a cikin coagulation kuma yana haɓaka tarin platelet.Lokacin da preeclampsia ya faru, matakan Fg suna ƙaruwa sosai, kuma lokacin da aikin coagulation na jiki ya lalace, matakan Fg a ƙarshe suna raguwa.Yawancin bincike na baya-bayan nan sun nuna cewa matakin Fg a lokacin shigar da ɗakin haihuwa shine mafi mahimmancin ma'ana don tsinkayar abin da ya faru na zubar da jini bayan haihuwa.Madaidaicin ƙimar tsinkaya shine 100% [7].A cikin uku na uku, plasma Fg gabaɗaya shine 3 zuwa 6 g/L.Yayin kunna coagulation, mafi girman plasma Fg yana hana hypofibrinemia na asibiti.Sai kawai lokacin da plasma Fg> 1.5 g / L zai iya tabbatar da aikin coagulation na al'ada, lokacin da plasma Fg <1.5 g / L, kuma a lokuta masu tsanani Fg <1 g / L, ya kamata a biya hankali ga hadarin DIC, kuma ya kamata a yi nazari mai zurfi. za'ayi.Mayar da hankali ga canje-canje na bidirectional na Fg, abun ciki na Fg yana da alaƙa da ayyukan thrombin kuma yana taka muhimmiyar rawa a cikin tsarin tarawar platelet.A cikin lokuta tare da Fg mai girma, ya kamata a ba da hankali ga nazarin alamun hypercoagulability da ƙwayoyin rigakafi na autoimmune [8].Gao Xiaoli da Niu Xiumin[9] sun kwatanta abin da ke cikin plasma Fg na mata masu juna biyu masu ciwon sukari mellitus da mata masu juna biyu na yau da kullun, kuma sun gano cewa abun ciki na Fg yana da alaƙa da alaƙa da ayyukan thrombin.Akwai halin zuwa thrombosis.