Jiki na yau da kullun yana da cikakken tsari na coagulation da tsarin rigakafin jini.Tsarin coagulation da tsarin rigakafi suna kiyaye daidaito mai ƙarfi don tabbatar da hemostasis na jiki da santsin jini.Da zarar ma'aunin aikin coagulation da anticoagulation ya rikice, zai haifar da zub da jini da yanayin thrombosis.

1. Aikin coagulation na jiki

Tsarin coagulation na jini ya ƙunshi abubuwan haɗin gwiwa.Abubuwan da ke cikin coagulation kai tsaye ana kiran su abubuwan coagulation.Akwai abubuwan coagulation guda 13 da aka sani.

Akwai hanyoyin kunnawa na endogenous da hanyoyin kunnawa waje don kunna abubuwan coagulation.

A halin yanzu an yi imani da cewa kunna tsarin coagulation na exogenous wanda aka fara ta hanyar ƙwayar nama yana taka muhimmiyar rawa wajen farawa na coagulation.Haɗin kusanci tsakanin tsarin coagulation na ciki da na waje yana taka muhimmiyar rawa wajen farawa da kiyaye tsarin coagulation.

2. Aikin maganin jini na jiki

Tsarin rigakafi ya haɗa da tsarin rigakafin ƙwayar cuta ta salon salula da tsarin rigakafin cututtukan jini.

①Tsarin maganin ciwon zuciya

Yana nufin phagocytosis na coagulation factor, nama factor, prothrombin hadaddun da kuma soluble fibrin monomer ta mononuclear-phagocyte tsarin.

②Tsarin rigakafin cutar hawan jini

Ciki har da: serine protease inhibitors, furotin C-based protease inhibitors da nama factor pathway inhibitors (TFPI).

3. Fibrinolytic tsarin da ayyukansa

Yawanci sun haɗa da plasminogen, plasmin, plasminogen activator da fibrinolysis inhibitor.

Matsayin tsarin fibrinolytic: narkar da ɗigon fibrin kuma tabbatar da santsin jini;shiga cikin gyaran nama da farfadowa na jijiyoyin jini.

4. Matsayin ƙwayoyin endothelial na jijiyoyi a cikin tsarin coagulation, anticoagulation da fibrinolysis.

① Samar da abubuwa daban-daban masu aiki na halitta;

② Daidaita coagulation na jini da aikin anticoagulation;

③ Daidaita aikin tsarin fibrinolysis;

④ Daidaita tashin hankali na jijiyoyin jini;

⑤ Shiga cikin tsaka-tsaki na kumburi;

⑥ Kula da aikin microcirculation, da dai sauransu.

Coagulation da cututtukan anticoagulant

1. Rashin daidaituwa a cikin abubuwan coagulation.

2. Rashin daidaituwa na abubuwan anticoagulant a cikin plasma.

3. Rashin daidaituwa na fibrinolytic factor a cikin jini.

4. Rashin al'ada na ƙwayoyin jini.

5. Marasa lafiya.