Lokacin Prothrombin (PT) alama ce mai mahimmanci don yin la'akari da aikin hanta, aikin ajiyewa, tsananin cututtuka da tsinkaye.A halin yanzu, ganewar asibiti na abubuwan coagulation ya zama gaskiya, kuma zai samar da bayanai a baya kuma mafi inganci fiye da PT wajen yin la'akari da yanayin cutar hanta.

Aikace-aikacen asibiti na PT a cikin cututtukan hanta:

Gidan gwaje-gwajen yana ba da rahoton PT ta hanyoyi huɗu: aikin prothrombintime kashi PTA (prothrombin time ratio PTR) da daidaitaccen rabo na duniya INR.Siffofin guda huɗu suna da ƙimar aikace-aikacen asibiti daban-daban.

Ƙimar aikace-aikacen PT a cikin cututtukan hanta: PT an ƙayyade shi ne ta hanyar matakin coagulation factor IIvX wanda hanta ya hada, kuma rawar da yake da shi a cikin cututtukan hanta yana da mahimmanci.Halin rashin daidaituwa na PT a cikin ciwon hanta mai tsanani shine 10% -15%, hepatitis na kullum shine 15% -51%, cirrhosis shine 71%, kuma hanta mai tsanani shine 90%.A cikin ka'idojin bincike na kwayar cutar hanta a cikin 2000, PTA yana daya daga cikin alamun bayyanar cututtuka na marasa lafiya tare da kwayar cutar hepatitis.Marasa lafiya na ciwon hanta na yau da kullun tare da m PTA>70%, matsakaici 70% -60%, mai tsanani 60% -40%;cirrhosis tare da ramuwa mataki PTA>60% decompensated mataki PTA <60%;PTA mai tsanani <40%" A cikin rarrabuwa na Child-Pugh, 1 aya don tsawaitawar PT na 1 ~ 4s, maki 2 don 4 ~ 6s, maki 3 don> 6s, tare da sauran alamun 4 (albumin, bilirubin, ascites, encephalopathy ), aikin hanta na marasa lafiya da ciwon hanta an raba su zuwa maki ABC; MELD score (Modelfor end-stageliver disease), wanda ke ƙayyade tsananin cutar a cikin marasa lafiya da ciwon hanta na ƙarshe da kuma tsarin dashen hanta, da dabarar ita ce .8xloge[bilirubin (mg/dl)+11.2xloge(INR)+ 9.6xloge[creatinine (mg/dl]+6.4x (dalilin: biliary ko barasa 0; sauran 1), INR na daya daga cikin alamomin 3.

Ka'idojin bincike na DIC don cututtukan hanta sun haɗa da: Tsawaitawar PT don fiye da 5s ko kunna lokaci na thromboplastin (APTT) fiye da 10s, factor VIII aiki <50% (da ake bukata);Ana amfani da PT da ƙididdigar platelet sau da yawa don kimanta biopsy hanta da tiyata Halin zubar jini na marasa lafiya, irin su platelets <50x10°/L, da tsawaitawar PT da ya wuce al'ada don 4s sune contraindications ga biopsy hanta da tiyata ciki har da dashen hanta.Ana iya ganin cewa PT yana taka muhimmiyar rawa wajen ganowa da kuma kula da marasa lafiya da ciwon hanta.