Aikace-aikacen D-dimer a cikin COVID-19


Marubuci: Magaji   

Fibrin monomers a cikin jini ana haɗa su ta hanyar kunna factor X III, sa'an nan kuma hydrolyzed ta hanyar kunna plasmin don samar da wani takamaiman samfurin lalata da ake kira "fibrin deradation Product (FDP)."D-Dimer shine FDP mafi sauƙi, kuma karuwa a cikin taro mai yawa yana nuna yanayin hypercoagulable da hyperfibrinolysis na biyu a cikin vivo.Sabili da haka, ƙaddamarwa na D-Dimer yana da mahimmanci ga ganewar asali, ƙimar inganci da kuma yanke hukunci game da cututtuka na thrombotic.

Tun bayan barkewar COVID-19, tare da zurfafa bayyanar cututtuka na asibiti da fahimtar cututtukan cututtukan cututtukan cututtukan cuta da kuma tarin ganowa da ƙwarewar jiyya, marasa lafiya masu ƙarfi da sabon ciwon huhu na jijiyoyin jini na iya haɓaka haɓakar ƙwayar cuta mai saurin numfashi.Alamu, girgiza mai rauni, refractory metabolic acidosis, rashin aiki na coagulation, da gazawar gabbai da yawa.D-dimer yana haɓaka a cikin marasa lafiya da ciwon huhu mai tsanani.
Marasa lafiya masu tsananin rashin lafiya suna buƙatar kula da haɗarin thromboembolism venous (VTE) saboda tsawan hutun gado da rashin aikin coagulation na al'ada.
A lokacin aikin jiyya, ya zama dole don saka idanu masu dacewa bisa ga yanayin, ciki har da alamomin zuciya na zuciya, aikin coagulation, da dai sauransu Wasu marasa lafiya na iya kara yawan myoglobin, wasu lokuta masu tsanani na iya ganin ƙarar troponin, kuma a lokuta masu tsanani, D-dimer ( D-Dimer) na iya ƙaruwa.

DD

Ana iya ganin cewa D-Dimer yana da mahimmancin saka idanu da ke da alaƙa a cikin ci gaban COVID-19, don haka ta yaya yake taka rawa a wasu cututtuka?

1. thromboembolism na jini

An yi amfani da D-Dimer sosai a cikin cututtukan da ke da alaƙa da venous thromboembolism (VTE), irin su thrombosis mai zurfi (DVT) da embolism na huhu (PE).Gwajin D-Dimer mara kyau na iya kawar da DVT, kuma ana iya amfani da maida hankali na D-Dimer don hango komowar adadin VTE.Binciken ya gano cewa haɗarin haɗari na sake dawowa na VTE a cikin yawan jama'a tare da mafi girma ya ninka sau 4.1 fiye da yawan jama'a tare da maida hankali na al'ada.

D-Dimer kuma ɗaya daga cikin alamun gano PE.Ƙimar hasashensa mara kyau yana da girma sosai, kuma mahimmancinsa shine ware m embolism na huhu, musamman ma marasa lafiya da ƙananan zato.Sabili da haka, ga marasa lafiya da ake zargi da mummunan ciwon huhu na huhu, ultrasonography na jijiyoyi mai zurfi na ƙananan ƙafar ƙafa da jarrabawar D-Dimer ya kamata a haɗa su.

2. Yaduwa coagulation na intravascular

Yaduwa coagulation na intravascular (DIC) wani ciwo ne na asibiti wanda ke da ciwon jini da gazawar microcirculatory akan cututtuka da yawa.Tsarin ci gaba ya ƙunshi tsarin da yawa kamar coagulation, anticoagulation, da fibrinolysis.D-Dimer ya karu a farkon mataki na samuwar DIC, kuma maida hankali ya ci gaba da karuwa fiye da sau 10 yayin da cutar ta ci gaba.Sabili da haka, ana iya amfani da D-Dimer a matsayin ɗaya daga cikin manyan alamomi don farkon ganewar asali da yanayin kulawa na DIC.

3. Ragewar Aortic

"Ijma'in ƙwararrun ƙwararrun kasar Sin game da ganewar asali da kuma kula da cututtukan zuciya" ya nuna cewa D-Dimer, a matsayin gwajin gwaji na yau da kullum don maganin ciwon ciki (AD), yana da matukar muhimmanci ga ganewar asali da bambancin ganewar cututtuka.Lokacin da D-Dimer na mai haƙuri ya tashi da sauri, yiwuwar kamuwa da cutar ta AD yana ƙaruwa.A cikin sa'o'i 24 da farawa, lokacin da D-Dimer ya kai mahimmancin ƙimar 500 μg/L, hankalinsa don bincikar m AD shine 100%, kuma ƙayyadaddun sa shine 67%, don haka ana iya amfani da shi azaman maƙasudin cirewa don gano cutar m AD.

4. Atherosclerotic cututtukan zuciya

Atherosclerotic cututtukan zuciya da jijiyoyin jini cuta ne cututtukan zuciya da ke haifar da plaque arteriosclerotic, gami da haɓakar ST-segment myocardial infarction, wanda ba na ST-segment mai girma myocardial infarction, da kuma m angina.Bayan fashewar plaque, kayan aikin necrotic a cikin plaque yana fitowa, yana haifar da abubuwan da ke gudana na jini mara kyau, kunna tsarin coagulation, da kuma ƙara yawan D-Dimer.Marasa lafiya na cututtukan zuciya tare da haɓakar D-Dimer na iya yin hasashen haɗarin AMI mafi girma kuma ana iya amfani dashi azaman mai nuni don lura da yanayin ACS.

5. Thrombolytic far

Nazarin Lawter ya gano cewa magungunan thrombolytic daban-daban na iya kara yawan D-Dimer, kuma ana iya amfani da shi a matsayin ma'auni don yin hukunci game da maganin thrombolytic.Abin da ke ciki ya karu da sauri zuwa matsayi mafi girma bayan thrombolysis, kuma ya koma baya a cikin ɗan gajeren lokaci tare da gagarumin ci gaba a cikin alamun asibiti, yana nuna cewa maganin yana da tasiri.

- Matsayin D-Dimer ya karu sosai daga awa 1 zuwa 6 bayan thrombolysis don myocardial infarction da ƙwayar cuta ta cerebral.
- A lokacin DVT thrombolysis, D-Dimer kololuwa yawanci faruwa 24 hours ko daga baya